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…showed last 75 words of 496 total…which symbolizes the loss of George after shooting Lennie. This was a truly great loss for him since Lennie was his best friend. Of Mice and Men is a very sad and depressing story that contains many deaths of many living creatures. Many people had a loss from these deaths, especially George. He had to shoot his best friend. This can possibly be the greatest loss of all, because without friends, where would we be?